Clinical Research

Clinically Proven, Scientifically Backed

LLLT stands for Low-Level Light Therapy, a clinically proven technology that delivers low-intensity red and near-infrared light to the skin. This light is absorbed by your cells’ mitochondria—the energy centers—helping to increase ATP, reduce inflammation, and support natural healing processes. It's safe, painless, and widely used in wellness, dermatology, and rehabilitation.

A growing body of peer-reviewed clinical research—spanning thousands of published studies from institutions like NASA, Harvard, and Mayo Clinic—has shown that Low-Level Light Therapy (LLLT) delivers measurable, effective results. Today, LLLT is widely accepted in mainstream healthcare and aesthetics, used to treat a growing range of medical and wellness concerns.
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Low-Level Light Therapy Research
Decades of research and thousands of clinical studies have consistently demonstrated the wide-ranging biological effects and therapeutic benefits of Low-Level Light Therapy (LLLT) and red light therapy when applied to the human body.

Low-Level Light Therapy（4 studies）

Key Evidence on Red & Near-Infrared Light for Pain Management（4 studies）

Clinical Evidence for Red Light in Skin Repair & Rejuvenation（4 studies）

Clinically Proven to Modulate and Revive the Body’s Natural Immune Response（4 studies）

Key Clinical & Preclinical Evidence for Red Light Reducing Inflammation（4 studies）

Key Clinical Evidence: Red & NIR Light for Performance & Recovery（4 studies）

Clinical Evidence for Mood & Depression（4 studies）

STEP 1

STEP 1

Light Energy Emitted as Photons
Hello Face L6 uses advanced red and near-infrared LEDs
to emit gentle, non-ionizing light energy—delivered as photons.
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STEP 2

STEP 2

Photons are Absorbed in the Mitochondria
When absorbed by the mitochondria (the energy centers of your cells),
light photons are transformed into ATP—your cell’s main fuel source
for repair, renewal, and healthy function.
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STEP 3

STEP 3

How ATP Fuels a Chain Reaction of Healing and Repair
ATP is the molecule that fuels cellular metabolism. Red and near-infrared light
boosts ATP production, activating key biological processes like RNA transcription,
protein synthesis, and natural repair of DNA, cells, and tissues.This therapy also
promotes nitric oxide (NO) release to improve circulation and reduce inflammation,
while balanced reactive oxygen species (ROS) signal cellular defense and repair.
The result is enhanced regeneration—including new blood vessels (angiogenesis),
nerve cells (neurogenesis), and the clearance of damaged tissue (phagocytosis)—
all contributing to faster recovery and healthier skin.
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Photobiomodulation, in other words, red light therapy, has proven effective against carpal tunnel syndrome, mucositis, neck pain, menstrual cramps, temporomandibular joint pain, and neuropathic pain from amputation. It also significantly reduces the pain of hypersensitivity while improving sensorimotor function.
These improvements come after anti-inflammatory cells populate the injured area, providing long-lasting pain relief. In addition, it’s also been shown to provide effective relief by affecting the following:
  • Represses cyclooxygenase and prostaglandins.
  • Activating peripheral opioid receptors.
  • Increasing endorphins serotonin release.
  • Stimulates the metabolism.
  • Changes nerve transmission.
Red light therapy has proven to be highly effective in rapidly treating wounds from burns, scars, bedsores, ulcers, surgery incisions, and diabetic neuropathy.
NASA strongly supports this claim as this technology was used in treating wounds. Red and near-infrared light proves effective in all four phases of the wound-healing process:
  • Coagulation
  • Inflammation
  • Migration
  • Remodeling
These processes are regulated by various factors connected via nitric oxide (NO) signaling release, adjusted by light energy.
An issue the body encounters when trying to heal a wound is low oxygen flow, and red light increases the flow of oxygen, speeding up the natural healing process. By reducing inflammation and increasing oxygenation of the wounded area, blood vessels can form, rapidly repairing the area, lessening pain and scarring.
By reducing pain, red light therapy eliminates the reliant on pharmaceutical painkillers during the healing process.
The human body receives energy on the cellular level, maintaining communication between organs and ensuring disease resistance.
A strong immune system works to protect the body from harmful bacteria and viruses at all times. With red light therapy, the body receives a boost of support as it releases nitric oxide and melatonin, two components involved in DNA repair and antimicrobial.
This process is called hormesis. Red and near-infrared wavelengths penetrate through the skin into the cells, causing mild metabolic stress, which stimulates cells to activate their anti-inflammatory and antioxidant response.
With the support of red light therapy, the body is better prepared to fight infections. Numerous studies have proven red light therapy to have the following effects on the immune system:
  • Improves melatonin production
  • Increases nitric oxide (NO) levels
  • Improves antioxidant production
  • Improves thyroid function
  • Stimulates T cells pre-operatively
  • Increases flow of neurotransmitters
  • Boosts collagen and elastin production
  • Encourages lymph node activity
  • Enables the transportation of immune cells
  • Stimulates optimal function of cells and organelles
Inflammation in the body can be acute and topical (short-term, resulting from sprains, infections, and accidents) or chronic and general (long-term, caused by ongoing conditions).
Acute inflammation is a healthy bodily response; however, chronic and general inflammation can negatively impact long-term health.
As of today, the current treatment for inflammation is NSAID or steroid drugs, both having a detrimental effect on the healing process and long-term health. Red light therapy stimulates the body to activate its natural healing mechanism, reducing the health risks of long-term drug use.
Red light therapy decreases the number of inflammatory cells, increases fibroblast proliferation (cells that synthesize collagen and other matrix macromolecules), stimulates angiogenesis (creation of new blood vessels), and activates the body’s anti-inflammatory, antioxidant response.
The following conditions are connected with chronic and acute inflammation, all proving promising results with red light therapy treatment:
  • Arthritis
  • Asthma
  • Sinusitis
  • Muscular sprains
  • Fibro-myalgia
  • Neuron inflammatory disorders such as Alzheimer’s
  • Irritable bowel syndrome and colitis
  • Rheumatic conditions
Red light therapy is extremely popular in competitive sports and performance. It offers natural and non-pharmaceutical treatment, which applies to many areas of the body.
Aside from the overwhelming benefits on overall health, red light therapy encourages muscles growth and repair by stimulating the production of ATP, which aids in faster recovery and better performance.
Red light therapy used before training prepares and strengthens the body while aiding muscle recovery after training.
Here are the scientifically documented effects of red light therapy:
  • Reducing DOMS (Delayed Onset Muscle Soreness)
  • Enhanced endurance and performance
  • Increasing sleep quality
  • Improving sexual function and libido (including Testosterone)
  • Aiding weight loss
  • Boosting cognitive function
  • Reversing skin aging
  • Reducing cellulite
Seasonal affective disorder (SAD) is a form of depressions, impacting 5% of Americans, specifically during the winter when there’s less natural sunlight. SAD is also known as seasonal depression or winter blues.
Many people treat SAD symptoms via bright white light treatment, mimicking the sun’s light daily. However, researchers recommend natural light treatment, like red light therapy, to help with light deficiency. Over recent years, physicians recommend red light therapy alongside psychotherapy and medication.

Hello Face L6

PDT Photons Facial Body Skin Care Home Device

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How Can Hello Face Help You?

Bringing Professional Light Therapy to the Comfort of Your Home.

Yes. Both bright light and low-level red/NIR light have been shown in clinical studies to alleviate symptoms of depression and SAD by influencing circadian rhythms and improving mood-related biomarkers.

With consistent use, red light therapy has shown lasting benefits, especially in chronic conditions. Many trials report sustained improvements over weeks or even months post-treatment.

Yes. Devices with safe irradiance levels (~40mW/cm²), clinically relevant wavelengths (630–850nm), and consistent proximity have shown effectiveness and safety in home-use trials.